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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2A
All Species:
37.58
Human Site:
Y251
Identified Species:
63.59
UniProt:
Q9BY44
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9BY44
NP_114414.2
585
64990
Y251
D
K
T
G
A
S
Y
Y
G
E
Q
T
L
H
Y
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001108004
580
64436
Y246
D
K
T
G
A
S
Y
Y
G
E
Q
T
L
H
Y
Dog
Lupus familis
XP_534306
585
65159
Y251
D
K
T
G
A
S
Y
Y
G
E
Q
T
L
H
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q8BJW6
581
64385
Y251
D
K
T
G
A
S
Y
Y
G
E
Q
T
L
H
Y
Rat
Rattus norvegicus
NP_001102809
541
60196
P243
I
Y
D
V
A
W
N
P
S
S
T
E
F
C
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507598
493
54394
S195
D
V
A
W
N
A
S
S
T
E
F
C
A
V
Y
Chicken
Gallus gallus
Q5ZKC1
586
64485
Y251
D
K
T
G
A
S
Y
Y
G
E
Q
T
L
H
Y
Frog
Xenopus laevis
Q7ZY11
582
64798
Y253
D
K
T
G
A
S
Y
Y
G
E
Q
T
L
H
Y
Zebra Danio
Brachydanio rerio
Q4QRJ7
580
64206
Y250
D
K
T
G
A
S
Y
Y
G
E
Q
T
L
H
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VNX8
638
70052
Y267
D
K
S
G
A
S
Y
Y
G
N
Q
A
V
H
F
Honey Bee
Apis mellifera
XP_625143
577
65273
Y250
D
K
T
G
A
S
Y
Y
G
K
Q
T
L
H
Y
Nematode Worm
Caenorhab. elegans
Q19052
570
64001
G254
K
T
N
Q
S
Y
Y
G
E
Q
S
L
Y
L
I
Sea Urchin
Strong. purpuratus
XP_001186352
299
33040
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53235
642
71286
Y269
Y
Y
G
E
N
T
L
Y
L
L
S
F
Q
G
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
97.4
96
N.A.
92.8
82.5
N.A.
74.5
84.4
74.8
69.5
N.A.
39
43.9
35.7
29.2
Protein Similarity:
100
N.A.
98.2
98.2
N.A.
95.5
87
N.A.
79.4
91.6
86.5
81.5
N.A.
56.5
61.3
54.8
40
P-Site Identity:
100
N.A.
100
100
N.A.
100
6.6
N.A.
20
100
100
100
N.A.
66.6
93.3
6.6
0
P-Site Similarity:
100
N.A.
100
100
N.A.
100
6.6
N.A.
26.6
100
100
100
N.A.
86.6
100
20
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
26.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
45.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
72
8
0
0
0
0
0
8
8
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
8
0
8
0
% C
% Asp:
72
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
8
0
0
0
0
8
58
0
8
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
8
8
8
0
8
% F
% Gly:
0
0
8
65
0
0
0
8
65
0
0
0
0
8
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
65
0
% H
% Ile:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% I
% Lys:
8
65
0
0
0
0
0
0
0
8
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
8
0
8
8
0
8
58
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
0
15
0
8
0
0
8
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
8
0
0
0
0
0
8
65
0
8
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
8
0
8
65
8
8
8
8
15
0
0
0
0
% S
% Thr:
0
8
58
0
0
8
0
0
8
0
8
58
0
0
0
% T
% Val:
0
8
0
8
0
0
0
0
0
0
0
0
8
8
8
% V
% Trp:
0
0
0
8
0
8
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
15
0
0
0
8
72
72
0
0
0
0
8
0
65
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _